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Depression Clinics

St. Louis & St. Charles County, MO

Find depression care that fits, including TMS and Spravato.

An independent, plain-language directory of local providers who treat depression, from everyday care to modern options like TMS and Spravato for people whose antidepressants have not worked. You do not have to wait until you have tried everything. Browse real clinics by location, treatment, and insurance.

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6 established providers Independent & not a clinic Reviewed for accuracy

A note before you browse

You do not have to wait until you have tried everything.

Depression that has not lifted is reason enough to look into care. Modern options are more available, and closer to home, than most people think. Whether you are just starting to ask questions or your antidepressants have stopped working, the providers below treat depression at every stage.

Morning light falling across a windowsill with a warm cup of tea and small potted plants

Showing local and regional providers. Listings are for information only; confirm details and availability directly with each clinic.

Brain Recovery Centers

St. Peters, MO - serving St. Charles & St. Louis County • Doctor-supervised outpatient clinic

Featured

A Missouri mental-health clinic focused on treatment-resistant depression and PTSD. Offers FDA-approved Spravato (esketamine), TMS, and related therapies under physician supervision, with most insurance accepted including MO HealthNet (Missouri Medicaid). Based in St. Peters, the clinic serves both St. Charles County and St. Louis County, in person and by telemedicine, including communities like St. Charles, O'Fallon, Wentzville, Lake Saint Louis, Cottleville, Dardenne Prairie, Chesterfield, Wildwood, Town and Country, and Ballwin.

Spravato (esketamine) TMS Treatment-resistant depression PTSD Most insurance / MO HealthNet
Visit brainrecoverycenters.com Learn about Spravato
Disclosure: Brain Recovery Centers is this directory's featured (sponsored) local provider. We highlight them because they serve the St. Louis / St. Charles County area and offer the treatments many readers search for. Their placement does not imply they are the only or best option for you. The other providers below are listed on their own merits and are not sponsored.
Other local & regional providers

Washington University Psychiatry (WashU Medicine)

St. Louis, MO (Central West End)•Academic medical center

The psychiatry department of Washington University School of Medicine, affiliated with Barnes-Jewish Hospital. Provides evaluation and treatment for mood disorders, including specialty and research-based care for hard-to-treat depression.

Medication managementMood disordersAcademic / research care

Saint Louis Behavioral Medicine Institute (SSM Health)

St. Louis, MO•Behavioral health clinic

A long-established outpatient behavioral health group, part of SSM Health, offering psychiatry and psychology services for depression, anxiety, OCD, and related conditions across several St. Louis locations.

Talk therapyPsychiatryAnxiety & depression

Mercy Behavioral Health

St. Louis & St. Charles County, MO•Hospital-affiliated

Behavioral health services within the Mercy hospital system, including outpatient psychiatry and counseling for depression and anxiety, with clinics across the greater St. Louis region.

PsychiatryCounselingMultiple locations

BJC Behavioral Health

St. Louis, MO•Community mental health center

A community mental health center serving the St. Louis area, providing psychiatric care, case management, and support for people with serious and persistent mental illness, including those using Medicaid.

Community mental healthMedicaid-friendlyCase management

Compass Health Network

St. Charles County & regional Missouri•Nonprofit health network

A nonprofit provider with clinics across Missouri offering behavioral health, primary care, and substance-use services on a sliding scale, and accepting Medicaid and uninsured patients.

Sliding scaleBehavioral healthMedicaid / uninsured

Know a St. Louis area provider that should be listed? This directory profiles established, verifiable clinics only. We do not list providers we cannot confirm.

Recommended local provider

Whose antidepressants have stopped working?

If you live in St. Louis or St. Charles County and standard antidepressants have not helped, a clinic that offers newer options like Spravato and TMS may be worth asking about. Brain Recovery Centers is a doctor-supervised local clinic focused specifically on treatment-resistant depression and PTSD, and accepts most insurance including MO HealthNet. Based in St. Peters, the clinic serves both St. Charles County and St. Louis County, in person and by telemedicine, including communities like O'Fallon, Wentzville, Chesterfield, and Ballwin.

Visit Brain Recovery Centers

Disclosure: Brain Recovery Centers is a recommended partner of this directory. Always talk with a qualified clinician about what is right for you.

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Depression treatment options compared Therapy, medication, TMS, Spravato, and ketamine, side by side. Spravato providers in St. Louis What esketamine is, who it is for, and where to find it locally. Ketamine vs Spravato How the two differ and which one insurance actually covers. TMS providers in St. Louis How transcranial magnetic stimulation works and who offers it. When antidepressants stop working What treatment-resistant depression means and the options next. PTSD treatment in St. Louis Proven options and how PTSD and depression overlap. Depression care in St. Charles County Local options in St. Peters, O'Fallon, Wentzville, and nearby. How to choose a depression provider Questions to ask and red flags to avoid. Insurance & cost in Missouri Coverage, MO HealthNet, and what to expect to pay. Depression treatment FAQ Straight answers to the questions people ask most.